CXCR4-Lo polyclonal, anti-human
€396.00
In stock
SKU
253817
Catalog Nr.: 253817
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The alpha-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites. This antibody is specific for the longer isoform of CXCR4.
Alternate Names: CXCR4-Lo, Fusin, LESTR, HUMSTR
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500
Accession No.: NP_001008540
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human CXCR4-Lo.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by ion exchange chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The alpha-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites. This antibody is specific for the longer isoform of CXCR4.
Alternate Names: CXCR4-Lo, Fusin, LESTR, HUMSTR
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500
Accession No.: NP_001008540
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human CXCR4-Lo.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by ion exchange chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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