Cyclin C polyclonal, anti-human, mouse, rat, bovine, dog, chicken

Protein Family: Enzymes, Protein Kinases, Transcription Factors

Pathway and Disease: Replication and Repair, Signal Transduction, Signaling Molecules and Interaction, Transcription

Description:
Cyclin-C (CCNC) forms the CDK8 module with CDK8, MED12, MED13, which decreases transcriptional activation when combined with the Mediator complex. The Mediator complex is a large protein complex composed of almost 30 different MED proteins that regulates transcription of nearly all RNA polymerase II (RNApII)-dependent genes, conveying information from gene-specific regulatory proteins. Mediator serves as a scaffold for the assembly of the functional preinitiation complex that includes RNApII. Cyclin-C-bound CDK8 phosphorylates the C-terminal domain of the large subunit of RNApII, inhibiting the formation of a transcription initiation complex. Cyclin-C is phosphorylated upon DNA damage, probably by ATM or ATR.

Alternate Names: Cyclin-C, Cyclin C, SRB11, CCNC

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P24863

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin C.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.