Cyclin D1 (clone ), anti-human, mouse, rat
€347.00
In stock
SKU
251740
Catalog Nr.: 251740
Size: 0.1 mg
Isotype: Mouse IgG2a
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Mouse IgG2a
Applications: E, WB, IHC
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Cell Communication, Signal Transduction, Cell Growth and Death, Cancers, Infectious Diseases
Description:
G1/S-specific cyclin-D1 (cyclin D1) is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.
Alternate Names: Cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, BCL-1 oncogene, BCL1, PRAD1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500
Accession No.: P24385
Antigen: Recombinant human cyclin D1 protein.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zhu J. et al. 2015. Mol Med Rep. doi:10.3892/mmr.2015.3284. PMID#25634369. Activin A regulates proliferation, invasion and migration in osteosarcoma cells.
Pathway and Disease: Cell Communication, Signal Transduction, Cell Growth and Death, Cancers, Infectious Diseases
Description:
G1/S-specific cyclin-D1 (cyclin D1) is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.
Alternate Names: Cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, BCL-1 oncogene, BCL1, PRAD1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500
Accession No.: P24385
Antigen: Recombinant human cyclin D1 protein.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zhu J. et al. 2015. Mol Med Rep. doi:10.3892/mmr.2015.3284. PMID#25634369. Activin A regulates proliferation, invasion and migration in osteosarcoma cells.
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