Cyclin D1 polyclonal, anti-human, mouse, rat, dog

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Cancers, Replication and Repair, Signal Transduction

Description:
Cyclin-D1 (BCL-1) complexes with CDK4 and CDK6 serine/threonine protein kinases to impart substrate specificity. Cyclin-D1 is essential for G1/S phase transition. Following DNA damage, Cyclin-D1 is phosphorylated at Thr-286 by MAP kinases, leading to its FBXO31-mediated ubiquitination and subsequent degradation. Chromosomal aberrations of CCND1 lead to various neoplastic and proliferative disorders.

Alternate Names: Cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, BCL-1 oncogene, BCL1, PRAD1, B-cell lymphoma 1 protein, CCND1, Cyl-1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P25322

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the central region of rodent Cyclin-D1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.