Cyclin O (N-term) polyclonal, anti-human, mouse, rat

Protein Family: Enzymes

Pathway and Disease: Cell Growth and Death, Replication and Repair, Signaling Molecules and Interaction

Description:
Cyclin O (CCNO) has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to intrinsec apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Suppression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. This protein was previously called UNG2 after being erroneously identified as a uracil DNA glycolase, but later identified as a cyclin protein family member. This antibody binds to the two isoforms of Cyclin O.

Alternate Names: Cyclin O, CCNO, cyclin-O

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: NP_066970

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Cyclin O.

Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.