Cytokeratin-1 polyclonal, anti-human, mouse, rat

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Signaling Molecules and Interaction

Description:
Cytokeratin-1 regulates the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma, also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persists into adulthood

Alternate Names: Cytokeratin-1, Cytokeratin-8, Cytokeratin-19, Keratin, type II cytoskeletal 1, CK-1, Keratin-1, K1, 67 kDa cytokeratin, Type-II keratin Kb1, Hair alpha protein, KRT1, KRTA, CK-8, Cytokeratin-8, Keratin, type II cytoskeletal 8, CK-8, Keratin-8, K8, KRT8, CYK8, Keratin, type I cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P04264; P05787; P08727

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human cytokeratin-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.