Cytokeratin-16 polyclonal, anti-human, mouse, rat

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Signaling Molecules and Interaction

Description:
Keratin, type I cytoskeletal 16 (cytokeratin-16) Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Defects in cytokeratin-16 are a cause of pachyonychia congenita type 1 (PC1), also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis.

Alternate Names: Cytokeratin-16, Keratin, type 1 cytoskeletal 16, CK-16, Keratin-16, K16, KRT16, KRT16A

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500

Accession No.: P08779

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human cytokeratin-16.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.