DARPP-32 (Thr34) polyclonal, anti-human, mouse, bovine, dog, chicken
€440.00
In stock
SKU
252531
Catalog Nr.: 252531
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Neurodegenerative Disorders, Nervous and Sensory Systems
Description:
Protein phosphatase 1 regulatory subunit 1B (DARPP-32) is expressed in dopaminergic neurons. DARPP-32 is a dopamine and cyclic-AMP regulated phosphoprotein. DARPP-32 levels are decreased in the dorsolateral prefrontal cortex and lymphocytes of both schizophrenia and bipolar disorder patients. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission.
Alternate Names: Protein phosphatase 1 regulatory subunit 1B, DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein, Ppp1r1b
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: Q6J4I0
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding phosphoThr34 of rat DARPP-32.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Neurodegenerative Disorders, Nervous and Sensory Systems
Description:
Protein phosphatase 1 regulatory subunit 1B (DARPP-32) is expressed in dopaminergic neurons. DARPP-32 is a dopamine and cyclic-AMP regulated phosphoprotein. DARPP-32 levels are decreased in the dorsolateral prefrontal cortex and lymphocytes of both schizophrenia and bipolar disorder patients. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission.
Alternate Names: Protein phosphatase 1 regulatory subunit 1B, DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein, Ppp1r1b
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: Q6J4I0
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding phosphoThr34 of rat DARPP-32.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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