Daxx polyclonal, anti-human, mouse
€396.00
In stock
SKU
253315
Catalog Nr.: 253315
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
Alternate Names: Daxx , Daxx
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500
Accession No.: CAG33366
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human Daxx.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by DEAE chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
Alternate Names: Daxx , Daxx
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500
Accession No.: CAG33366
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human Daxx.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by DEAE chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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