DBC1 (clone 3G4), anti-human, mouse, rat, monkey
€388.00
In stock
SKU
MB0057
Background:
Core component of the DBIRD complex,a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing:the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions.Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis.Inhibits SUV39H1 methyltransferase activity.As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
Alternative Name:
DBC1, DBC-1, NET35, p30DBC, p30 DBC, DBC.1, DBIRD complex subunit, KIAA1967
Application Dilution: WB: 1:500~1000, ICC: 1:50~200
Specificity: This antibody detects endogenous levels of DBC1 and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human KIAA1967.
MW: Predicted band size: 103kDa, Observed band size: 120kDa,
Swis Prot.: Q8N163
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Core component of the DBIRD complex,a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing:the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions.Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis.Inhibits SUV39H1 methyltransferase activity.As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
Alternative Name:
DBC1, DBC-1, NET35, p30DBC, p30 DBC, DBC.1, DBIRD complex subunit, KIAA1967
Application Dilution: WB: 1:500~1000, ICC: 1:50~200
Specificity: This antibody detects endogenous levels of DBC1 and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human KIAA1967.
MW: Predicted band size: 103kDa, Observed band size: 120kDa,
Swis Prot.: Q8N163
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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