DCC polyclonal, anti-human, mouse, rat

Protein Family: Cell Adhesion Molecules

Pathway and Disease: Cell Growth and Death, Nervous and Sensory Systems, Neurodegenerative Disorders

Description:
Netrin receptor DCC (DCC) is a receptor for netrin, which is required for axon guidance. DCC mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. DCC also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Defects in DCC are the cause of congenital mirror movements Mirror movements are contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.

Alternate Names: DCC, Deleted in colorectal cancer gene, Deleted in colorectal cancer, Netrin receptor DCC, Tumor suppressor protein DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, IGDCC1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P43146

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DCC.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.