DDX58 polyclonal, anti-human
€347.00
In stock
SKU
252167
Catalog Nr.: 252167
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Enzymes
Pathway and Disease: Infectious Diseases, Immune System
Description:
Probable ATP-dependent RNA helicase DDX58 (DDX58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, DDX58 triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). DDX58 detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). DDX58 is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
Alternate Names: Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I, DDX58
Application Notes: E: 1:10,000-1:50,000; WB: 1:500-1:2,000
Accession No.: O95786
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DDX58.
Format: Each vial contains 0.1 mL of crude serum with 0.09% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Infectious Diseases, Immune System
Description:
Probable ATP-dependent RNA helicase DDX58 (DDX58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, DDX58 triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). DDX58 detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). DDX58 is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
Alternate Names: Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I, DDX58
Application Notes: E: 1:10,000-1:50,000; WB: 1:500-1:2,000
Accession No.: O95786
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DDX58.
Format: Each vial contains 0.1 mL of crude serum with 0.09% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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