DJ-1 polyclonal, anti-human, mouse, rat, bovine, horse, pig
€362.00
In stock
SKU
251668
Catalog Nr.: 251668
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, FC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, FC
Protein Family: Enzymes, Peptidases
Pathway and Disease: Neurodegenerative Disorders
Description:
Protein DJ-1 (DJ-1, PARK7) protects cells against oxidative stress and cell death. DJ-1 plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. DJ-1 eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. DJ-1 acts as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide.
Alternate Names: Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; FC: 1:100
Accession No.: Q99497
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DJ-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Neurodegenerative Disorders
Description:
Protein DJ-1 (DJ-1, PARK7) protects cells against oxidative stress and cell death. DJ-1 plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. DJ-1 eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. DJ-1 acts as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide.
Alternate Names: Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; FC: 1:100
Accession No.: Q99497
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DJ-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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