Dnmt3b polyclonal, anti-human, mouse

Protein Family: Enzymes

Pathway and Disease: Amino Acid Metabolism, Replication and Repair

Description:
Dnmt3B is required for genome wide de novo methylation and is essential for development. Defects in Dnmt3B are a cause of immunodeficiency-centromeric instability-facial abnomalies syndrome (ICF), characterized biochemically by hypomethylation of CpG sites in heterochromatin.

Alternate Names: DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: Q9UBC3, NP_008823

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Dnmt3b.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.