Dopamine D2 Receptor polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction, Cell Communication

Description:
D(2) dopamine receptor (dopamine D2 receptor) is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Genetic variations in the dopamine D2 receptor are implicated in the genetic susceptibility to alcoholism. Genetic variations in the dopamine D2 receptor are a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.

Alternate Names: D(2) dopamine receptor, Dopamine D2 receptor, Dopamine receptor D2, DRD2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P14416

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human dopamine D2 receptor.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Sakano D et al. 2016. Stem Cell Reports. 7(1): 95-109. PMID 27373926.