DR-4 polyclonal, anti-human

Protein Family: Receptors and Channels

Pathway and Disease: Signaling Molecules and Interaction, Immune System

Description:
HLA class II histocompatibility antigen, DRB1-4 beta chain (DR-4) is a heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. DR-4 binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases.

Alternate Names: HLA class II histocompatibility antigen, DRB1-4 beta chain, MHC class II antigen DRB1*4, DR-4, DR4, HLA-DRB1

Application Notes: E: 1:10,000-1:50,000; WB: 1:100-1:1,000

Accession No.: P13760

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DR-4.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.