DR5 polyclonal, anti-human, mouse

Protein Family: Cellular Antigens, Receptors and Channels

Pathway and Disease: Cell Growth and Death, Immune System, Infectious Diseases, Signaling Molecules and Interaction

Description:
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB. This antibody is specific for DR5 and does not react with DR4.

Alternate Names: DR5, TRAIL-R2, Apo2, TRICK2, KILLER, CD262, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TRAIL receptor 2, TNFRS10B, TNF-related apoptosis-inducing ligand receptor 2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500; IF: 1:50-1:200

Accession No.: AF012535

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DR5.

Format: Each vial contains 0.1 mg IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.