DR6 polyclonal, anti-human

Protein Family: Enzymes

Pathway and Disease: Signaling Molecules and Interaction

Description:
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappaB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.

Alternate Names: DR6

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: AF068868

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human DR6.

Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by DEAE chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.