DRAK2 polyclonal, anti-human
€396.00
In stock
SKU
253346
Catalog Nr.: 253346
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
Alternate Names: DRAK2 , DRAK2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500
Accession No.: AB011421
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human DRAK2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by ion exchange chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
Alternate Names: DRAK2 , DRAK2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500
Accession No.: AB011421
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human DRAK2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by ion exchange chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
| Is Featured? | No |
|---|
Write Your Own Review