DsbA-L polyclonal, anti-human, mouse
€363.00
In stock
SKU
253133
Catalog Nr.: 253133
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Endocrine System, Energy Metabolism, Lipid Metabolism
Description:
Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution. DcbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis.
Alternate Names: DsbA-L, Disulfide-bond-A oxidoreductase-like protein
Application Notes: E: 1:500-1:1,000; WB: 1:2000; IHC: 1:200
Accession No.: Q9Y2Q3
Antigen: Recombinant mouse DsbA-L protein.
Format: Each vial contains 0.1 mL of crude serum, 40% glyerol with 0.065% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Endocrine System, Energy Metabolism, Lipid Metabolism
Description:
Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution. DcbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis.
Alternate Names: DsbA-L, Disulfide-bond-A oxidoreductase-like protein
Application Notes: E: 1:500-1:1,000; WB: 1:2000; IHC: 1:200
Accession No.: Q9Y2Q3
Antigen: Recombinant mouse DsbA-L protein.
Format: Each vial contains 0.1 mL of crude serum, 40% glyerol with 0.065% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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