CD324 (E-Cadherin) polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS72286
Background:
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Alternative Name:
Cadherin-1, Cadherin1, Cadherin 1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, CDH1, CDHE, UVO
Application Dilution: WB: 1:500 - 1:1000, IF: 1:50 - 1:200
Specificity: E-Cadherin polyclonal antibody detects endogenous levels of E-Cadherin protein.
Immunogen:
A synthetic peptide of human CDH1
MW: 130kDa
Swis Prot.: P12830
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Alternative Name:
Cadherin-1, Cadherin1, Cadherin 1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, CDH1, CDHE, UVO
Application Dilution: WB: 1:500 - 1:1000, IF: 1:50 - 1:200
Specificity: E-Cadherin polyclonal antibody detects endogenous levels of E-Cadherin protein.
Immunogen:
A synthetic peptide of human CDH1
MW: 130kDa
Swis Prot.: P12830
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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