Ecarin polyclonal, anti-

Protein Family: Enzymes, Peptidases, CAM Ligands

Pathway and Disease: Signaling Molecules and Interaction

Description:
Ecarin is a snake venom zinc metalloproteinase that catalyzes the conversion of prothrombin (F2) to alpha-thrombin through formation of a thrombin intermediate. It has a low Km for prothrombin and a high kcat. It cleaves the 320-Arg-Ile-321 bond in prothrombin and produces meizothrombin which is ultimately converted to alpha-thrombin by autolysis. Ecarin MW is about 45 kDa after processing of propeptide with blood clotting activity.

Alternate Names: Ecarin, Zinc metalloproteinase-disintegrin-like ecarin, Snake venom metalloproteinase, SVMP

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q90495

Antigen: Ecarin purified from snake venom

Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.