Ectodysplasin-A polyclonal, anti-human, mouse, rat
€347.00
In stock
SKU
251518
Catalog Nr.: 251518
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cytokines
Pathway and Disease: Signaling Molecules and Interaction
Description:
Ectodysplasin-A is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 of ectodysplasin-A binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in ectodysplasin-A are the cause of ectodermal dysplasia type 1 (ED1), also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
Alternate Names: ED1, Ectodysplasin-A, Ectodermal dysplasia protein, EDA protein, EDA, EDA2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q92838
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Ectodysplasin-A.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Li Y et al. 2011. Int J Nanomedicine 6:815-823. PMID: 21589649.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Ectodysplasin-A is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 of ectodysplasin-A binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in ectodysplasin-A are the cause of ectodermal dysplasia type 1 (ED1), also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
Alternate Names: ED1, Ectodysplasin-A, Ectodermal dysplasia protein, EDA protein, EDA, EDA2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q92838
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Ectodysplasin-A.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Li Y et al. 2011. Int J Nanomedicine 6:815-823. PMID: 21589649.
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