Eg5 / KIF11 (clone ), anti-human
€388.00
In stock
SKU
MB0012
Background:
Eg5 (also known as Kinesin-like protein KIF11 or TRIP5) is a slow, plus-end-directed microtubule-based motor of the BimC kinesin family that is essential for bipolar spindle formation during eukaryotic cell division. When the expression of Eg5 is blocked, centrosome migration halts and cells are arrested in mitosis with monoastral microtubule arrays. Eg5 is phosphorylated on serine during S phase and on both serine and Thr 927 during mitosis, which regulates the association of Eg5 with the spindle apparatus (probably during early prophase). Eg5 is also known to be a member of the thyroid receptor interacting protein (TRIP) family, and interacts with the thyroid hormone receptor only in the presence of thyroid hormone.
Alternative Name:
Kinesin-like protein KIF11, Kinesin-like protein 1, Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5, Thyroid receptor-interacting protein 5, TR-interacting protein 5, TRIP-5, KIF11, EG5, KNSL1, TRIP5
Application Dilution: WB: 1:1000, ICC: 1:200, IP: 1:50~1:200
Specificity: This antibody detects endogenous levels of KIF11 and does not cross-react with related proteins
Immunogen:
Recombinant full length Human Eg5.
MW: Predicted band size: 120KDa, Observed band size: 130KDa, Additional band size: 75K
Swis Prot.: P52732
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Eg5 (also known as Kinesin-like protein KIF11 or TRIP5) is a slow, plus-end-directed microtubule-based motor of the BimC kinesin family that is essential for bipolar spindle formation during eukaryotic cell division. When the expression of Eg5 is blocked, centrosome migration halts and cells are arrested in mitosis with monoastral microtubule arrays. Eg5 is phosphorylated on serine during S phase and on both serine and Thr 927 during mitosis, which regulates the association of Eg5 with the spindle apparatus (probably during early prophase). Eg5 is also known to be a member of the thyroid receptor interacting protein (TRIP) family, and interacts with the thyroid hormone receptor only in the presence of thyroid hormone.
Alternative Name:
Kinesin-like protein KIF11, Kinesin-like protein 1, Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5, Thyroid receptor-interacting protein 5, TR-interacting protein 5, TRIP-5, KIF11, EG5, KNSL1, TRIP5
Application Dilution: WB: 1:1000, ICC: 1:200, IP: 1:50~1:200
Specificity: This antibody detects endogenous levels of KIF11 and does not cross-react with related proteins
Immunogen:
Recombinant full length Human Eg5.
MW: Predicted band size: 120KDa, Observed band size: 130KDa, Additional band size: 75K
Swis Prot.: P52732
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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