EGFR (clone 5E9), anti-human

Background:
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.

Synonyms: Epidermal growth factor receptor, erbb 1, Receptor tyrosine protein kinase ErbB 1

Cellular Location: Secreted Cell membrane

Immunogen:
A synthetic peptide coupled to KLH

Gene Symbol: EGFR

Gene ID: 1956

Swiss prot: P00533

Calculated MW: 170kDa

Recommended dilution:
WB 1:1000-3000, IP 1:100-300, IF 1:100-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.