EGFR (E746-A750del Specific) [clone MD26R], anti-human

Description: Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, which occurs in exon 21 and short in-frame deletions in exon 19. A common lesion in exon 19 is the deletion of E746-A750, although other variants occur. IHC-based EGFR E746-A750del specific antibody is designed to detect deletion of E746-A750 in exon 19. Deletion in exon 19 is associated with response of non-small cell lung carcinoma (NSCLC) to gefitinib or erlotinib monotherapy.Localization: membraneDilution: PredilutedPositive Control: lung ca. E746-A750del specificHIER: citrate pH6.0 or EDTA pH8.0Status: RUO