EGFRvIII (clone 2C10) , anti-human, mouse, rat
€388.00
In stock
SKU
MB8018
Background:
EGFR variant III (EGFRvIII) is a truncated, constitutively active mutant form of EGFR that results from an in-frame deletion of exons 2-7. EGFRvIII is expressed in various cancers, most notably glioblastoma, where it is expressed at a frequency of 25-30%. Although complicated by the fact that it is often co-expressed with amplified EGFR, EGFRvIII is a potential therapeutic target.
Alternative Name:
EGFR vIII, EGFR class lII variant, EGF Receptor vIII, EGFR variant III
Application Dilution: WB: 1:500~1:1000
Specificity: EGFR vlII mAb detects endogenous levels of EGFR vlII protein.
Immunogen:
A synthetic peptide corresponding to residues in Human EGFRvIII Peptide (LEEKKGNYVVTDHC).
MW: ~ 170 kDa
Swis Prot.: P00533
Purification & Purity:
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
EGFR variant III (EGFRvIII) is a truncated, constitutively active mutant form of EGFR that results from an in-frame deletion of exons 2-7. EGFRvIII is expressed in various cancers, most notably glioblastoma, where it is expressed at a frequency of 25-30%. Although complicated by the fact that it is often co-expressed with amplified EGFR, EGFRvIII is a potential therapeutic target.
Alternative Name:
EGFR vIII, EGFR class lII variant, EGF Receptor vIII, EGFR variant III
Application Dilution: WB: 1:500~1:1000
Specificity: EGFR vlII mAb detects endogenous levels of EGFR vlII protein.
Immunogen:
A synthetic peptide corresponding to residues in Human EGFRvIII Peptide (LEEKKGNYVVTDHC).
MW: ~ 170 kDa
Swis Prot.: P00533
Purification & Purity:
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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