EIF2C2 polyclonal, anti-human, mouse, rat

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Folding, Sorting and Degradation

Description:
Eukaryotic translation initiation factor 2C 2 (EIF2C2) is required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include EIF2C2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target.

Alternate Names: Protein argonaute-2, Argonaute2, hAgo2, Protein slicer, Slicer, PAZ Piwi domain protein, PPD, Eukaryotic translation initiation factor 2C 2, eIF-2C 2, eIF2C 2

Application Notes: E: 1:10,000-1:80,000; WB: 1:100-1:,000

Accession No.: Q9UKV8

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EIF2C2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.