EP300 (clone 7D8A6), anti-human
€394.00
In stock
SKU
252813
Catalog Nr.: 252813
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Protein Family: Enzymes
Pathway and Disease: Signal Transduction, Cancers
Description:
EP300 (E1A binding protein p300) is an adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It is a histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. p300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this protein cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Alternate Names: EP300 protein, p300, KAT3B
Application Notes: WB: 1:500-1:2000
Accession No.: Q7Z6C1
Antigen: Purified recombinant fragment of EP300 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signal Transduction, Cancers
Description:
EP300 (E1A binding protein p300) is an adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It is a histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. p300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this protein cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Alternate Names: EP300 protein, p300, KAT3B
Application Notes: WB: 1:500-1:2000
Accession No.: Q7Z6C1
Antigen: Purified recombinant fragment of EP300 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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