ER-alpha (clone 2B7), anti-human
€297.00
In stock
SKU
252635
Catalog Nr.: 252635
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: WB, IHC
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: WB, IHC
Protein Family: Receptors and Channels, Transcription Factors
Pathway and Disease: Cancers, Signaling Molecules and Interaction, Transcription
Description:
Estrogen and progesterone receptors are members of a family transcription that are regulated by the binfing of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors.
Alternate Names: Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: P19785
Antigen: Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Signaling Molecules and Interaction, Transcription
Description:
Estrogen and progesterone receptors are members of a family transcription that are regulated by the binfing of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors.
Alternate Names: Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: P19785
Antigen: Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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