ER-alpha (N-term) polyclonal, anti-human, mouse, rat, chicken

Protein Family: Transcription Factors, Receptors and Channels

Pathway and Disease: Transcription

Description:
The estrogen receptor (ER-alpha) is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. ER-alpha can activate the transcriptional activity of TFF1. ER-alpha binds DNA as a homodimer, and can form a heterodimer with ESR2. ER-alpha interacts with FOXC2, MAP1S, SLC30A9, UBE1C and the coactivators NCOA3, NCOA5, NCOA6, and NCOA7. Genetic variations in ER-alpha are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture.

Alternate Names: Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P03372

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ER-alpha.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.