ER-beta (N-term) polyclonal, anti-human, mouse, rat, monkey, chimpanzee

Protein Family: Receptors and Channels, Transcription Factors

Pathway and Disease: Transcription

Description:
Estrogen receptor beta (ER-beta) is a nuclear hormone receptor. ER-beta binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. ER-beta binds DNA as a homodimer, and can form a heterodimer with ESR1. ER-beta interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes.

Alternate Names: Estrogen receptor, ER, Estrogen receptor-beta, Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q92731

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ER-beta.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.