ER780 Anti-Human CD197/CCR7 Antibody [clone G043H7]
€0.00
In stock
SKU
E-AB-F1159S
Catalog Number: E-AB-F1159S
Reactivity: Human, Clone: G043H7
Isotype: Mouse IgG2a, κ, Conjugation: ER780
Applications: FCM
Datasheet, Questions? Contact us!
Reactivity: Human, Clone: G043H7
Isotype: Mouse IgG2a, κ, Conjugation: ER780
Applications: FCM
Datasheet, Questions? Contact us!
Background:
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details
Synonyms:
CMKBR7, EBI1, EVI1, CCR-7, CDw197
Swissprot: P32248
Buffer: PBS with 0.05% Proclin300, 1% BSA
Storage:
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details
Synonyms:
CMKBR7, EBI1, EVI1, CCR-7, CDw197
Swissprot: P32248
Buffer: PBS with 0.05% Proclin300, 1% BSA
Storage:
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
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