ERBB2 (clone 6C2), anti-human

Protein Family: Enzymes, Receptors and Channels, Protein Kinases

Pathway and Disease: Cancers, Development and Behavior, Cell Communication, Signaling Molecules and Interaction

Description:
ERBB2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2) is a neuro/glioblastoma derived oncogene homolog. It is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

Alternate Names: Receptor tyrosine protein kinase erbB2, p185erbB2, v-erbB-2, Neu proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, ERBB2, HER2, NEU, NGL

Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000;

Accession No.: P04626

Antigen: Purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.