ERK/MAPK polyclonal, anti-mouse, rat

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Cell Communication, Cancers, Cell Motility, Development and Behavior, Endocrine System, Immune System, Metabolic Disorders, Nervous and Sensory Systems, Signal Transduction

Description:
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42 encoded by ERK1 and ERK2 respectively. Both kinases are regulated by dual specific phosphorylation on tyrosine and threonine in response to insulin and NGF. ERK/MAPK is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. The activity of ERK/MAPK is regulated by dual phosphorylation at Thr202 and Tyr204.

Alternate Names: ERK-1, Mitogen-activated protein kinase 3, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 1, MAPK1, p44-ERK1, ERT2, p44-MAPK, Microtubule-associated protein 2 kinase, MAPK3, ERK1, PRKM3, and for ERK-2, Mitogen-activated protein kinase 1, Extracellular signal-regulated kinase 2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK2, p42-MAPK, ERT1, MAPK1, ERK2, PRKM1, PRKM2

Application Notes: E: 1:500-1:1,000; WB: 1:1,000

Accession No.: P63086

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of rat ERK/MAPK.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.