Exostosin-1 polyclonal, anti-human, mouse, xenopus, zebrafish

Protein Family: Enzymes

Pathway and Disease: Cancers, Glycan Biosynthesis and Metabolism

Description:
Exostosin-1 (EXT1) is a glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. EXT1 is a tumor suppressor. Defects in EXT1 are the cause of multiple exostoses disorders, i.e. skeletal deformities and bone tumors.

Alternate Names: Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Putative tumor suppressor protein EXT1, Multiple exostoses protein 1, EXT1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: Q16394, NP_000118

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Exostosin-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 10% glycerol with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.