Factor I (clone KT22), anti-human
€354.00
In stock
SKU
250120
Catalog Nr.: 250120
Size: 0.1 mg
Isotype: mouse IgG2b
Applications: E
Size: 0.1 mg
Isotype: mouse IgG2b
Applications: E
Protein Family: Enzymes, Peptidases
Pathway and Disease: Immune System
Description:
The complement factor I is responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. These protein cleavages inactivate complement components C3b, iC3b and C4b. Factor I consists of a heterodimer of a light and heavy chains linked by disulfide bonds. Factor I deficiencies (CFI) result in increasing risks for pyrogenic infections, such as hemolytic uraemic syndrome (HUS), an acute renal failure in childhood due to E. coli infection. This antibody recognizes human complement factor I in ELISA.
Alternate Names: Complement factor I, C3B/C4B inactivator, Factor I heavy chain, Factor I light chain, CFI, IF
Application Notes: E: 5 mg/ml
Accession No.: P05156, NP_000195
Antigen: Purified human complement factor I protein
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Immune System
Description:
The complement factor I is responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. These protein cleavages inactivate complement components C3b, iC3b and C4b. Factor I consists of a heterodimer of a light and heavy chains linked by disulfide bonds. Factor I deficiencies (CFI) result in increasing risks for pyrogenic infections, such as hemolytic uraemic syndrome (HUS), an acute renal failure in childhood due to E. coli infection. This antibody recognizes human complement factor I in ELISA.
Alternate Names: Complement factor I, C3B/C4B inactivator, Factor I heavy chain, Factor I light chain, CFI, IF
Application Notes: E: 5 mg/ml
Accession No.: P05156, NP_000195
Antigen: Purified human complement factor I protein
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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