FADD polyclonal, anti-human, mouse, rat

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Cell Growth and Death, Immune System, Cancers, Neurodegenerative Disorders, Infectious Diseases

Description:
FAS-associated death domain protein (FADD) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. FADD is involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Defects in FADD are the cause of recurrent infections associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM). IEHDCM is a condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4-CD8-TCR-alpha-beta+ T-cell counts, and elevated IL10 and FASL levels.

Alternate Names: FADD, Protein FADD, Fas-associated protein with death domain, FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Growth-inhbiting gene 3 protein, MORT1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500

Accession No.: Q13158

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human FADD.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.