FAK (clone 10H7), anti-human, mouse

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Signaling Molecules and Interaction, Cell Motility, Cell Communication, Immune System, Infectious Diseases, Cancers

Description:
FAK (Focal adhesion kinase) is a 1074 -amino acid protein (~118 kDa). It is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. FAK is concentrated at the basal edge of only basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds, activated and localized to the focal adhesions of spreading keratinocytes in culture. Thus, it has been postulated that FAK may have an important in vivo role in the re-epithelialization of human wounds. FAK protein tyrosine kinase activity has also been shown to increase in cells stimulated to grow by use of mitogenic neuropeptides or neurotransmitters acting through G protein-coupled receptors.

Alternate Names: Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK FAK, FAK1, PTK2

Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000

Accession No.: Q05397

Antigen: Purified recombinant fragment of human FAK expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.