FBLN5 (clone 1G6A4), anti-human
€443.00
In stock
SKU
252764
Catalog Nr.: 252764
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC
Protein Family: CAM Ligands
Pathway and Disease: Cell Communication
Description:
FBLN5 (Fibulin 5) is a 448-amino acid multifunctional extracellular matrix protein (~50kDa). It mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Alternate Names: Fibulin-5, Fibulin 5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50, FBLN5
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q9UBX5
Antigen: Purified recombinant fragment of FBLN5(aa242-448) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Communication
Description:
FBLN5 (Fibulin 5) is a 448-amino acid multifunctional extracellular matrix protein (~50kDa). It mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Alternate Names: Fibulin-5, Fibulin 5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50, FBLN5
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q9UBX5
Antigen: Purified recombinant fragment of FBLN5(aa242-448) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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