FGR (clone 6G2), anti-human, mouse
€443.00
In stock
SKU
252859
Catalog Nr.: 252859
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Protein Family: Enzymes, Protein Kinases, Receptors and Channels
Pathway and Disease: Cancers, Development and Behavior, Signal Transduction, Transcription
Description:
FGR (Gardner-Rasheed feline sarcoma viral oncogene homolog) is a member of the Src family of protein tyrosine kinases (PTKs). FGR contains N-terminal sites for myristylation and palmitylation, a PTK domain, SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene.
Alternate Names: Tyrosine-protein kinase Fgr, , Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr, SRC2 FGR
Application Notes: WB: 1:500-1:2000
Accession No.: P09769
Antigen: Purified recombinant fragment of human FGR expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Development and Behavior, Signal Transduction, Transcription
Description:
FGR (Gardner-Rasheed feline sarcoma viral oncogene homolog) is a member of the Src family of protein tyrosine kinases (PTKs). FGR contains N-terminal sites for myristylation and palmitylation, a PTK domain, SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene.
Alternate Names: Tyrosine-protein kinase Fgr, , Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr, SRC2 FGR
Application Notes: WB: 1:500-1:2000
Accession No.: P09769
Antigen: Purified recombinant fragment of human FGR expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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