Fibrillin-1 polyclonal, anti-human, mouse, rat

Protein Family: CAM Ligands

Pathway and Disease: Signaling Molecules and Interaction, Cell Motility

Description:
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Defects in fibrillin-1 are a cause of Marfan syndrome (MFS), an autosomal dominant disorder that affects the skeletal, ocular, and cardiovascular systems. A wide variety of skeletal abnormalities occurs with MFS, including scoliosis, chest wall deformity, tall stature, abnormal joint mobility.

Alternate Names: FBN1, Fibrillin-1, FBN 

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P35555

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human fibrillin-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.