Fractin polyclonal, anti-human, rat
€363.00
In stock
SKU
253137
Catalog Nr.: 253137
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Cell Growth and Death, Signaling Molecules and Interaction
Description:
During apoptosis, beta actin is cleaved by activated caspase 3 between Asp244 and Gly245. This cleavage results in the release of an approximately 130 amino acid (15 kDa) fragment from the C-terminus of beta actin and a 32 kDa (244 amino acid) N-terminal fragment of actin, known as fractin. The C -terminus of the fractin fragment represents an apoptosis-specific neoepitope that is not antigenic in native full-length beta actin and therefore presents a novel and specific marker for distinguishing apoptotic from necrotic cells.
Alternate Names: Actin, cytoplasmic 1, Beta-actin, ACTB
Application Notes: E: 1:500-1:1,000; WB: 1:1,000; IHC: 1:100
Accession No.: P60709
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human fractin.
Format: Each vial contains 0.1 ml of crude serum.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cell Growth and Death, Signaling Molecules and Interaction
Description:
During apoptosis, beta actin is cleaved by activated caspase 3 between Asp244 and Gly245. This cleavage results in the release of an approximately 130 amino acid (15 kDa) fragment from the C-terminus of beta actin and a 32 kDa (244 amino acid) N-terminal fragment of actin, known as fractin. The C -terminus of the fractin fragment represents an apoptosis-specific neoepitope that is not antigenic in native full-length beta actin and therefore presents a novel and specific marker for distinguishing apoptotic from necrotic cells.
Alternate Names: Actin, cytoplasmic 1, Beta-actin, ACTB
Application Notes: E: 1:500-1:1,000; WB: 1:1,000; IHC: 1:100
Accession No.: P60709
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human fractin.
Format: Each vial contains 0.1 ml of crude serum.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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