GABABR1 (Ser923) polyclonal, anti-human, mouse, rat, bovine
€440.00
In stock
SKU
252545
Catalog Nr.: 252545
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Receptors and Channels
Pathway and Disease: Nervous and Sensory Systems
Description:
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-Receptor, R-1 subunit), together with the GABA-Receptor, R-2 subunit, forms a receptor for GABA. The activity of GABA-B-Receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activates potassium channels, inactivate voltage-dependent calcium-channels and modulate inositol phospholipids hydrolysis. The GABA-B-Receptor plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-Receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. The GABA receptor has not only been implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Phosphorylation of Ser923 is important in the regulation of GABAB receptor function.
Alternate Names: Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1, Gabbr1
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: Q9Z0U4
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser923 of rat GABAB receptor, R1-subunit.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Nervous and Sensory Systems
Description:
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-Receptor, R-1 subunit), together with the GABA-Receptor, R-2 subunit, forms a receptor for GABA. The activity of GABA-B-Receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activates potassium channels, inactivate voltage-dependent calcium-channels and modulate inositol phospholipids hydrolysis. The GABA-B-Receptor plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-Receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. The GABA receptor has not only been implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Phosphorylation of Ser923 is important in the regulation of GABAB receptor function.
Alternate Names: Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1, Gabbr1
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: Q9Z0U4
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser923 of rat GABAB receptor, R1-subunit.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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