GAD-65 polyclonal, anti-human
€385.00
In stock
SKU
252176
Catalog Nr.: 252176
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Enzymes
Pathway and Disease: Amino Acid Metabolism, Endocrine System, Carbohydrate Metabolism
Description:
65 kDa glutamic acid decarboxylase (GAD-65) catalyzes the production of GABA. In mammals, GAD exists in two isoforms encoded by two different genes - Gad1 and Gad2. These isoforms are GAD-67 and GAD-65, with molecular weights of 67 and 65 kDa, respectively. GAD-67 and GAD-65 are expressed in the brain where GABA is used as a neurotransmitter, GAD-65 is also expressed in the pancreas. Both GAD-67 and GAD-65 are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes. Injections with GAD-65 has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.
Alternate Names: Glutamate decarboxylase 2, Glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD-65, GAD2, GAD65
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:500; IHC: 1:50-1:200
Accession No.: Q05329
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GAD-65.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Amino Acid Metabolism, Endocrine System, Carbohydrate Metabolism
Description:
65 kDa glutamic acid decarboxylase (GAD-65) catalyzes the production of GABA. In mammals, GAD exists in two isoforms encoded by two different genes - Gad1 and Gad2. These isoforms are GAD-67 and GAD-65, with molecular weights of 67 and 65 kDa, respectively. GAD-67 and GAD-65 are expressed in the brain where GABA is used as a neurotransmitter, GAD-65 is also expressed in the pancreas. Both GAD-67 and GAD-65 are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes. Injections with GAD-65 has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.
Alternate Names: Glutamate decarboxylase 2, Glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD-65, GAD2, GAD65
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:500; IHC: 1:50-1:200
Accession No.: Q05329
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GAD-65.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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