GAD-67 polyclonal, anti-human, mouse, rat, dog

Protein Family: Enzymes

Pathway and Disease: Amino Acid Metabolism, Carbohydrate Metabolism, Metabolic Disorders, Nervous and Sensory Systems

Description:
67 kDa glutamic acid decarboxylase (GAD-67) catalyzes the production of GABA, the main inhibitory neurotransmitter in the central nervous system. Defects in GAD-67 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1), a non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.

Alternate Names: GAD-67, Glutamate decarboxylase 67 kDa isoform, Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD1, GAD, GAD67 

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q99259

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GAD-67.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.