Galectin-3 human active recombinant protein
€295.00
In stock
SKU
600117
Protein Family: CAM Ligands, Glycan Binding Proteins
Pathway and Disease: Cancers, Cell Growth and Death, Signaling Molecules and Interaction
Alternate Names: galectin-3, galactose-specific lectin 3, mac-2 antigen, IgE binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Laminin-binding protein, Lectin L-29, L-31, Galactoside-binding protein, GALBP, LGALS3Description:
Recombinant Human Galectin-3 is a member of a large family of carbohydrate-binding proteins. Also known as Mac-2, L29and CBP35, Human Galectin-3 is expressed by a wide range of cell types including activated T-cells, tumor cells, macrophages, osteoclasts, fibroblasts and epithelial cells. Galectin-3 exhibits proinflammatory activities both in vitro and in vivo. Galectin-3 also chemoattracts monocytes and macrophages. Increased circulating levels of Galectin-3 correlate with several types of cancer, suggesting Galectin-3 is involved in tumor growth and metastasis. Human and Mouse Galectin-3 share 80% homology by amino acid sequence. Human Galectin-3 is a recombinant polypeptide chain consisting of 250 amino acids with a MW of 26 kDa.
Source: E. coli. Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Applications: E, WB
Application Notes:
Determined by its ability to chemoattract human blood monocytes. Chemotactic activity with a range of 2 ug/ml peaking at approximately 220 ug/ml.
Accession No.: P17931
MW: 26000 Da
Sequence:
ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI
Purity:
Purity > 97% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 50 ug protein lyophilized in 50 mM NaCl, 10 mM sodium phosphate pH7.5. Reconstitute with 0.5 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
Pathway and Disease: Cancers, Cell Growth and Death, Signaling Molecules and Interaction
Alternate Names: galectin-3, galactose-specific lectin 3, mac-2 antigen, IgE binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Laminin-binding protein, Lectin L-29, L-31, Galactoside-binding protein, GALBP, LGALS3Description:
Recombinant Human Galectin-3 is a member of a large family of carbohydrate-binding proteins. Also known as Mac-2, L29and CBP35, Human Galectin-3 is expressed by a wide range of cell types including activated T-cells, tumor cells, macrophages, osteoclasts, fibroblasts and epithelial cells. Galectin-3 exhibits proinflammatory activities both in vitro and in vivo. Galectin-3 also chemoattracts monocytes and macrophages. Increased circulating levels of Galectin-3 correlate with several types of cancer, suggesting Galectin-3 is involved in tumor growth and metastasis. Human and Mouse Galectin-3 share 80% homology by amino acid sequence. Human Galectin-3 is a recombinant polypeptide chain consisting of 250 amino acids with a MW of 26 kDa.
Source: E. coli. Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Applications: E, WB
Application Notes:
Determined by its ability to chemoattract human blood monocytes. Chemotactic activity with a range of 2 ug/ml peaking at approximately 220 ug/ml.
Accession No.: P17931
MW: 26000 Da
Sequence:
ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI
Purity:
Purity > 97% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 50 ug protein lyophilized in 50 mM NaCl, 10 mM sodium phosphate pH7.5. Reconstitute with 0.5 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
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