GAP-43 polyclonal, anti-human, mouse, rat, bovine, chicken

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Cell Growth and Death, Cell Motility, Development and Behavior, Nervous and Sensory Systems, Neurodegenerative Disorders

Description:
GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic axonal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC, PIP2, actin, calmodulin, spectrin, palmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.

Alternate Names: GAP-43, Growth-associated protein 43, Neuromodulin, Axonal membrane protein GAP-43, PP46, Neural phosphoprotein B-50, GAP43

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P17677

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GAP-43.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.