Gap-43 (Ser41) polyclonal, anti-human, mouse, bovine, dog, chicken, Xenopus, zebrafish
€440.00
In stock
SKU
252546
Catalog Nr.: 252546
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Cell Growth and Death, Cell Motility, Development and Behavior, Nervous and Sensory Systems, Neurodegenerative Disorders
Description:
GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic axonal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC, PIP2, actin, calmodulin, spectrin, palmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.
Alternate Names: GAP-43, Growth-associated protein 43, Neuromodulin, Axonal membrane protein GAP-43, PP46, Neural phosphoprotein B-50, GAP43
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P07936
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser41 of rat Gap-43.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cell Growth and Death, Cell Motility, Development and Behavior, Nervous and Sensory Systems, Neurodegenerative Disorders
Description:
GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic axonal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC, PIP2, actin, calmodulin, spectrin, palmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.
Alternate Names: GAP-43, Growth-associated protein 43, Neuromodulin, Axonal membrane protein GAP-43, PP46, Neural phosphoprotein B-50, GAP43
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P07936
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser41 of rat Gap-43.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
| Is Featured? | No |
|---|
Write Your Own Review