Gastric Inhibitory Polypeptide (clone ), anti-human
€559.00
In stock
SKU
250231
Catalog Nr.: 250231
Size: 0.1 mg
Isotype: Mouse IgG1/k
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Mouse IgG1/k
Applications: E, WB, IHC
Protein Family: Hormones
Pathway and Disease: Endocrine System, Signaling Molecules and Interactions
Description:
Human gastric inhibitory polypeptide (GIP) is a 42-amino-acid peptide belonging to the glucagon-secretin family of peptide hormones. It is secreted by endocrine cells in the duodenal mucosa and stimulates glucose-dependent insulin secretion as well as GLP-1 release from more distal endocrine (L) cells in the intestinal mucosa. GIP shows amino-acid sequence similarities to glucagon, GLP-1 and GLP-2 (from approximately 50% identity for glucagon to 30% identity for GLP-2). This antibody binds human GIP and cross-reacts up to 10% with PACAP and human GLP-2 but <0.1% with glucagon, GLP-1 or VIP. Cross-reactivity with porcine GIP has not been determined.
Alternate Names: Gastric inhibitory polypeptide, GIP, glucose-dependent insulinotropic polypeptide
Application Notes: The dilution guideline applies to glutaraldehyde-linked GIP-OA (molar ratio 4:1) coated at 1 µg/mL. With GIP coated directly at 2 µg/mL the dilution guideline is 1:2,000. In addition Product Cat. No. 250231 binds free GIP in solution. E: 1:10,000; WB:1:100-1:500; IHC:1:100-1:500
Accession No.: P09681
Antigen: Synthetic human gastric inhibitory polypeptide coupled to carrier.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Endocrine System, Signaling Molecules and Interactions
Description:
Human gastric inhibitory polypeptide (GIP) is a 42-amino-acid peptide belonging to the glucagon-secretin family of peptide hormones. It is secreted by endocrine cells in the duodenal mucosa and stimulates glucose-dependent insulin secretion as well as GLP-1 release from more distal endocrine (L) cells in the intestinal mucosa. GIP shows amino-acid sequence similarities to glucagon, GLP-1 and GLP-2 (from approximately 50% identity for glucagon to 30% identity for GLP-2). This antibody binds human GIP and cross-reacts up to 10% with PACAP and human GLP-2 but <0.1% with glucagon, GLP-1 or VIP. Cross-reactivity with porcine GIP has not been determined.
Alternate Names: Gastric inhibitory polypeptide, GIP, glucose-dependent insulinotropic polypeptide
Application Notes: The dilution guideline applies to glutaraldehyde-linked GIP-OA (molar ratio 4:1) coated at 1 µg/mL. With GIP coated directly at 2 µg/mL the dilution guideline is 1:2,000. In addition Product Cat. No. 250231 binds free GIP in solution. E: 1:10,000; WB:1:100-1:500; IHC:1:100-1:500
Accession No.: P09681
Antigen: Synthetic human gastric inhibitory polypeptide coupled to carrier.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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